Diethyl Ether → HCID 18313769, compound

Participants

Reaction Steps

A solution of ethanol/hydrochloric acid (6.8 ml, 6 N) is added to a solution of 4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-[4-(1H-1,2,4-triazol-1-yl)butyl]pyridine (11.5 g, 36.3 mmol) in absolute ethanol (50 ml) cooled on an ice bath. After a few minutes ethyl ether (200 ml) is added and a precipitate appears, which is filtered, washed with cold ethanol and dried, yielding 12 g (93%) of 4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-[4-(1H-1,2,4-triazol-1-yl)butyl]pyridine hydrochloride of m.p. 165-6° C.

Provenance & Evidence