Fumaric Acid → HCID 18313766, compound

Participants

Reaction Steps

A solution of fumaric acid (0.464 g, 4 mmol) in absolute ethanol (10 ml) is added to a solution of 4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-[4-(1H-1,2,4-triazol-1-yl)butyl]pyridine (1.26 g, 4 mmol) in isopropanol (12 ml) at 40° C. After about 20 minutes a precipitate appears, which is filtered after cooling to room temperature, washed with cold ethanol and dried, yielding 1.65 g (93%) of 4-(4-chlorophenyl)-1,2,3,6-tetrahydro-1-[4-(1H-1,2,4-triazol-1-yl)butyl]pyridine fumarate of m.p. 156-9° C.

Provenance & Evidence