HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 276971Generated: October 30, 2026
Malonic Acid → 2H-1-Benzopyran-3-carboxylic acid, 6-methyl-2-oxo-
https://huagongshe.com/reaction/276971
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Benzaldehyde, 2-hydroxy-5-methyl- | HCID 69184 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2H-1-Benzopyran-3-carboxylic acid, 6-methyl-2-oxo- | HCID 25090 | — |
Reaction Steps
2 g of 5-methylsalicylaldehyde (14.7 mmol), 3.06 g of malonic acid (29.4 mmol), 1.3 g of pyridine and 0.08 g of aniline are dissolved in a minimum amount of ethanol. The mixture is heated at 40° C. on a water bath for 6 h. Next, it is diluted with water, acidified and then extracted with ether. The solvent is removed by distillation under reduced pressure. The residue obtained is recrystallized from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06355658B1 |
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| Source dataset | uspto-grants-2002_03 |
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| ORD ID | ord-f1dfcf20fe7d423885f3648f9289de6e |
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| Source note | uspto-grants-2002_03 |
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