(E)-3-(2-methyl-pyridin-4-yl)-acrylonitrile → 2-Furan-2-yl-7-(2-methyl-pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

HRID 277017Notes

Reaction equation

HRID 277017 reaction equation
C1(S([CH2:10][C:11]2[N:15]=[C:14]([C:16]3[O:17][CH:18]=[CH:19][CH:20]=3)[NH:13][N:12]=2)(=O)=O)C=CC=CC=1.[CH3:21][C:22]1[CH:27]=[C:26](/[CH:28]=[CH:29]/[C:30]#[N:31])[CH:25]=[CH:24][N:23]=1>>[O:17]1[CH:18]=[CH:19][CH:20]=[C:16]1[C:14]1[N:15]=[C:11]2[CH:10]=[C:28]([C:26]3[CH:25]=[CH:24][N:23]=[C:22]([CH3:21])[CH:27]=3)[CH:29]=[C:30]([NH2:31])[N:12]2[N:13]=1

Participants

3

Reactant 2

HCID 18313596(E)-3-(2-methyl-pyridin-4-yl)-acrylonitrileHCID 178527402HCID 178527402, compound

Product 1

HCID 226296712-Furan-2-yl-7-(2-methyl-pyridin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

Procedure

The title compound, mp. 100-101° C. and MS (EI) m/e (%): 291 (M+, 100), was prepared in accordance with the general method of example 1 from 3-benzenesulfonylmethyl-5-furan-2-yl-1H-[1,2,4]triazole and (E)-3-(2-methyl-pyridin-4-yl)-acrylonitrile.

Sources & evidence

ORD record
ord-920313b184474a32a6ed9f2d15a31b1c
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

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