Phosphorus tribromide → HCID 12926387, compound

HRID 27702Notes

Reaction equation

HRID 27702 reaction equation
[O:1]([C:8]1[N:13]=[C:12]([CH2:14]O)[CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Br)(Br)[Br:17]>CCOCC>[O:1]([C:8]1[N:13]=[C:12]([CH2:14][Br:17])[CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 24614Phosphorus tribromide2×HCID 128791556-Phenoxy-2-pyridinemethanol

Product 1

HCID 12926387HCID 12926387, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To 8.45 mmol of (6-phenoxy-2-pyridyl)methanol in 75 ml ether is added, at -10°, 12.7 mmol of phosphorus tribromide. The solution is refluxed for 1 hour, after which approximately 1 ml of phosphorus tribromide is added and refluxing is continued for 2 hours. The reaction mixture is cooled to RT and resulting solid is filtered and washed with ether to yield the hydrogen bromide salt of (6-phenoxy-2-pyridyl)methyl bromide.

Workup

  1. temperatureThe solution is refluxed for 1 hour
  2. temperaturerefluxing
  3. customresulting solid
  4. filtrationis filtered
  5. washwashed with ether

Sources & evidence

ORD record
ord-1675f7aee05b4d32875532b26aa82379
Source dataset
uspto-grants-1980_09
Patent number
US04223033

Reaction notes

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