thiophene-2-carboxylic acid N'-(2-benzenesulfonyl-1-imino-ethyl)-hydrazide → HCID 178527403, compound

HRID 277029Notes

Reaction equation

HRID 277029 reaction equation
[C:1]1([S:7]([CH2:10][C:11]([NH:13][NH:14][C:15]([C:17]2[S:18][CH:19]=[CH:20][CH:21]=2)=O)=[NH:12])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C>[C:1]1([S:7]([CH2:10][C:11]2[N:12]=[C:15]([C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)[NH:14][N:13]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 178511478thiophene-2-carboxylic acid N'-(2-benzenesulfonyl-1-imino-ethyl)-hydrazide

Product 1

HCID 178527403HCID 178527403, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.00, (0.003 mol) Thiophene-2-carboxylic acid N′-(2-benzenesulfonyl-1-imino-ethyl)-hydrazide were heated at 200° C. for 20 minutes. The molten mass Bras then cooled, dissolved in 5 ml hot ethanol and stirred for one hour at room temperature. The precipitated crystals were filtered off and dried to yield 0.87 g (93%) 3-benzenesulfonylmethyl-5-thiophen-2-yl-1H-[1,2,4]triazole as yellow crystals with mp. 191-193° C. MS m/e (%): 305 (M+, 100).

Workup

  1. temperatureThe molten mass Bras then cooled
  2. filtrationThe precipitated crystals were filtered off
  3. customdried

Sources & evidence

ORD record
ord-336490c77b874892b265a1b4ae3aa038
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

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