Benzyl Bromide → HCID 22629692, compound

Participants

Reaction Steps

A solution of 0.20 g (0.0007 mol) 2-phenyl-7-pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine in 17.5 ml dimethylsulfoxide was treated with 0.69 g (0.01 mol) potassiumhydroxide(85%) for 20 minutes at room temperature. Then 0.26 g (0.0015 mol) benzylbromide were added and stirring was continued for 70 hours. Saturated aqueous sodiumbicarbonate was added and the mixture was extracted with chloroform. Evaporation of the solvent and chromatography on silicagel with dichloromethane/methanol 98/2 and crystallisation from diethylether gave 0.12 g (44%) dibenzyl-(2-phenyl-7-pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-amine as light brown crystals. MS m/e (%): 468 (M+H+, 100).

Provenance & Evidence