HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methyl-2-thiophenecarboxaldehyde → 7-Bromo-2-(3-methyl-thiophen-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methyl-2-thiophenecarboxaldehyde | HCID 79911 | — |
| Reactant | 4-Bromo-2,6-diaminopyridine | HCID 11435393 | — |
| Reactant | O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine | HCID 11830845 | — |
| Product | 7-Bromo-2-(3-methyl-thiophen-2-yl)-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 18313692 | — |
Reaction Steps
The title compound, MS m/e (%): 309 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and 3-methylthiophene-2-carboxaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06355653B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-e22fa2c3d371489a8a509ce5670f088a |
| Source note | uspto-grants-2002_03 |