1-Methyl-1H-pyrrole-2-carbaldehyde → HCID 18313605, compound

HRID 277066Notes

Reaction equation

HRID 277066 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:22])(=O)=O.[CH3:24][N:25]1[CH:29]=[CH:28][CH:27]=[C:26]1[CH:30]=O>>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]2[N:22]=[C:30]([C:26]3[N:25]([CH3:24])[CH:29]=[CH:28][CH:27]=3)[N:9]=[C:4]2[CH:3]=1

Participants

4

Reactant 3

HCID 145041-Methyl-1H-pyrrole-2-carbaldehydeHCID 114353934-Bromo-2,6-diaminopyridineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 18313605HCID 18313605, compound

Procedure

The title compound, MS m/e (%): 294 (M++2, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and 1-methylpyrrole-2-carboxaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

Sources & evidence

ORD record
ord-83b75458da734bbda918023044224b84
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

Loading…