4-Bromo-2,6-diaminopyridine → HCID 18313606, compound

HRID 277077Notes

Reaction equation

HRID 277077 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:22])(=O)=O.[CH3:24][O:25][C:26]1[CH:27]=[C:28]([CH:31]=O)[S:29][CH:30]=1>>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]2[N:22]=[C:31]([C:28]3[S:29][CH:30]=[C:26]([O:25][CH3:24])[CH:27]=3)[N:9]=[C:4]2[CH:3]=1

Participants

4

Reactant 3

HCID 114353934-Bromo-2,6-diaminopyridineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamineHCID 18313550HCID 18313550, compound

Product 1

HCID 18313606HCID 18313606, compound

Procedure

The title compound, MS m/e (%): 325 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and 4-methoxy-thiophene-2-carbaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

Sources & evidence

ORD record
ord-d4190ab0c2404f6b9b4b91bb2ee8c20c
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

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