5,6-dihydro-4H-pyran-2-carbaldehyde → HCID 18313583, compound

HRID 277078Notes

Reaction equation

HRID 277078 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:22])(=O)=O.[O:24]1[CH2:29][CH2:28][CH2:27][CH:26]=[C:25]1[CH:30]=O>>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]2[N:22]=[C:30]([C:25]3[O:24][CH2:29][CH2:28][CH2:27][CH:26]=3)[N:9]=[C:4]2[CH:3]=1

Participants

4

Reactant 3

HCID 111160165,6-dihydro-4H-pyran-2-carbaldehydeHCID 114353934-Bromo-2,6-diaminopyridineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 18313583HCID 18313583, compound

Procedure

The title compound, MS m/e (%): 295 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonylhydroxylamine, and 5,6-dihydro-4H-pyran-2-carbaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

Sources & evidence

ORD record
ord-86cb6dcc5bd448248450a19e8c74f638
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

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