o-Fluorobenzaldehyde → HCID 22629677, compound

HRID 277080Notes

Reaction equation

HRID 277080 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH2:9])[CH:3]=1.C1(C)C=C(C)C=C(C)C=1S(O[NH2:22])(=O)=O.[F:24][C:25]1[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=1[CH:27]=O>>[Br:1][C:2]1[CH:7]=[C:6]([NH2:8])[N:5]2[N:22]=[C:27]([C:26]3[CH:29]=[CH:30][CH:31]=[CH:32][C:25]=3[F:24])[N:9]=[C:4]2[CH:3]=1

Participants

4

Reactant 3

HCID 67970o-FluorobenzaldehydeHCID 114353934-Bromo-2,6-diaminopyridineHCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine

Product 1

HCID 22629677HCID 22629677, compound

Procedure

The title compound, MS m/e (%): 290 (M+, 100), was prepared in accordance with the general method of example 63 from 4-bromo-pyridine-2,6-diamine, O-mesitylene-sulfonyl-hydroxylamine, and 2-fluoro-benzaldehyde. The purification was performed with reversed phase HPLC eluting with an acetonitrile/water gradient.

Sources & evidence

ORD record
ord-7435ac5608aa404e959d59cde821fb10
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

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