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Morpholine → 7-Morpholin-4-yl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 7-Bromo-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 22629673 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-Morpholin-4-yl-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 18313627 | 49.1% |
反応手順
A mixture of 40 mg (0.138 mmol) 7-bromo-2-phenyl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, 241 μl (2.8 mmol) morpholin and 225 mg (0.69 mmol) CS2CO3 in 200 μl DMF was heated 20 h to 140° C. filtration and subsequent purification with reversed phase column chromatography with an acetonitrile/water gradient yielded 20 mg (49%) of the title compound, MS m/e M+H+ (100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06355653B1 |
| 出典データセット | uspto-grants-2002_03 |
| ORD ID | ord-53b5c452a47148e098a25edccc448b90 |
| 出典メモ | uspto-grants-2002_03 |