HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methyl-2-pyridylmethanol → 7-(6-Methyl-pyridin-2-ylmethoxy)-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methyl-2-pyridylmethanol | HCID 70736 | — |
| Reactant | 7-Bromo-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 22629706 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 7-(6-Methyl-pyridin-2-ylmethoxy)-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine | HCID 22629720 | — |
Reaction Steps
A mixture of 1 eq. 7-bromo-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, 5 eq. (6-methyl-pyridin-2-yl)-methanol and a catalytic amount of CS2CO3 in 200 μl N-methyl-pyrrolidon was heated for 2 h to 160°. The mixture was, after filtration, purified with reversed phase column chromatography eluting with an acetonitrile/water gradient yielding the title compound, MS m/e (%): 332 M+H+ (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06355653B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-52fdf304478d49b0a97cec170be12683 |
| Source note | uspto-grants-2002_03 |