反应详情

温度

80 °C

A mixture of 40.5 mg (0.21 mmol) 2,6-diamino-4-bromo-pyridine, 90.5 mg (0.47 mmol) 3,4-dichloro-phenyl-boronic acid, 7.8 mg (0.01 mmol) Dichloro(1,1′-bis(diphenylphosphino) ferrocene)palladium (II) dichloromethane adduct and 0.3 ml 2M Na2CO3 in 1 ml dimethoxyethane was heated to 80° C. for 17 h. The mixture was filtered over silica washed with MeOH/DCM and concentrated. The residue was taken up in 1 ml DMF and the totle compound was purified by reversed phase column chromatography eluting wit an acetonitrile/water gradient to yield 29 mg (52%), MS m/e (%): 254 M+ (100).

1. filtrationThe mixture was filtered over silica
2. washwashed with MeOH/DCM
3. concentrationconcentrated
4. customthe totle compound was purified by reversed phase column chromatography
5. washeluting wit an acetonitrile/water gradient
6. customto yield 29 mg (52%), MS m/e (%)