2,4-Difluoro-benzoic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazide → HCID 178527400, 화합물

HRID 277101노트

반응식

HRID 277101 반응식
[NH2:1][C:2](=[N:13][NH:14][C:15](=O)[C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=1[F:23])[CH2:3][S:4]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=[O:6])=[O:5]>C(O)C>[C:7]1([S:4]([CH2:3][C:2]2[N:1]=[C:15]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[F:23])[NH:14][N:13]=2)(=[O:6])=[O:5])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

3

반응물 1

HCID 700885692,4-Difluoro-benzoic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazide

생성물 1

HCID 178527400HCID 178527400, 화합물수율 71%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

8.0 g (0.023 mol) 2,4-Difluoro-benzoic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazide were heated at 210° C. for 20 minutes. The molten mass was then cooled, dissolved in 30 ml hot ethanol and stirred overnight at room temperature. The precipitated crystals were filtered off and dried to yield 5.35 g (71%) 3-benzenesulfonylmethyl-5-(2,4-difluoro-phenyl)-1H-[1,2,4]triazole as white solid, MS m/e (%): 336 (M+H+, 100).

후처리

  1. temperatureThe molten mass was then cooled
  2. filtrationThe precipitated crystals were filtered off
  3. customdried

출처 및 근거

ORD 기록
ord-14c8731cb56e48e49e5318c3fd3b0aea
출처 데이터셋
uspto-grants-2002_03
특허 번호
US06355653B1

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