(Z)-3-pyridin-2-yl-acrylonitrile → 2-(2,4-Difluoro-phenyl)-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

HRID 277103Notes

Reaction equation

HRID 277103 reaction equation
C1(S([CH2:10][C:11]2[N:15]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:17]=3[F:23])[NH:13][N:12]=2)(=O)=O)C=CC=CC=1.[N:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1/[CH:30]=[CH:31]\[C:32]#[N:33]>>[F:23][C:17]1[CH:18]=[C:19]([F:22])[CH:20]=[CH:21][C:16]=1[C:14]1[N:15]=[C:11]2[CH:10]=[C:30]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][N:24]=3)[CH:31]=[C:32]([NH2:33])[N:12]2[N:13]=1

Participants

3

Reactant 2

HCID 45116217(Z)-3-pyridin-2-yl-acrylonitrileHCID 178527400HCID 178527400, compound

Product 1

HCID 183136812-(2,4-Difluoro-phenyl)-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

Procedure

The title compound, MS m/e (%): 324(M+H+,100), was prepared in accordance with the general method of example 1 from 3-benzenesulfonylmethyl-5-(2,4-difluoro-phenyl)-1H-[1,2,4]triazole and (E)/(Z)-3-pyridin-2-yl-acrylonitrile.

Sources & evidence

ORD record
ord-48684a7929904ca1840468edcf8371a8
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

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