反应详情

15.0 g (0.047 mol) nicotinic acid (1-amino-2-benzenesulfonyl-ethylidene)-hydrazide were heated at 220° C. for 20 minutes. The molten mass was then cooled, dissolved in 100 ml hot ethanol and stirred overnight at room temperature. The precipitated crystals were filtered off and dried to yield 13.6 g (96%)) 3-(5-benzenesulfonylmethyl-2H-[1,2,4]triazol-3-yl)-pyridine as white solid, MS m/e (%): 300 (M+, 8), 236(99), 159 (100), 105(43), 77(35).

1. temperatureThe molten mass was then cooled
2. filtrationThe precipitated crystals were filtered off
3. customdried