(Z)-3-(5-chloro-pyridin-2-yl)-acrylonitrile → 7-(5-Chloro-pyridin-2-yl)-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

HRID 277114Notes

Reaction equation

HRID 277114 reaction equation
C1(S([CH2:10][C:11]2[N:12]=[C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[NH:14][N:15]=2)(=O)=O)C=CC=CC=1.[Cl:22][C:23]1[CH:24]=[CH:25][C:26](/[CH:29]=[CH:30]\[C:31]#[N:32])=[N:27][CH:28]=1>>[Cl:22][C:23]1[CH:24]=[CH:25][C:26]([C:29]2[CH:30]=[C:31]([NH2:32])[N:15]3[N:14]=[C:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=4)[N:12]=[C:11]3[CH:10]=2)=[N:27][CH:28]=1

Participants

3

Reactant 2

HCID 86757854(Z)-3-(5-chloro-pyridin-2-yl)-acrylonitrileHCID 178527399HCID 178527399, compound

Product 1

HCID 99271957-(5-Chloro-pyridin-2-yl)-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

Procedure

The title compound, MS m/e (%):323 (M+H+,100), was prepared in accordance with the general method of example 1 from 2-(5-benzenesulfonylmethyl-2H-[1,2,4]triazol-3-yl)-pyridine and (E)/(Z)-3-(5-chloro-pyridin-2-yl)-acrylonitrile.

Sources & evidence

ORD record
ord-4928c220fc9b4e1d85c95173f81dd66a
Source dataset
uspto-grants-2002_03
Patent number
US06355653B1

Reaction notes

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