反应详情

A solution of 0.16 g (0.00035 mol) 7-(6-chloro-pyridin-3-yl)-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine in 80 ml isopropylamine were stirred at 150° C. for 150 hours in an autoclav. Removal of the amine and chromatography on silicagel with dichloro-methane/methanol 9/1 gave 0.05 g (29%) 7-(6-isopropylamino-pyridin-3-yl)-2-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine as beige solid, MS m/e (%): 346 (M+H+,100).

1. customRemoval of the amine and chromatography on silicagel with dichloro-methane/methanol 9/1