2-Phenylethanol → 2-Phenethyloxy-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine

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Reaction Steps

0.06 g (0.003 mol) sodium in 50 ml 2-phenylethanol were stirred overnight at 60° C. 0.2 g (0.0007 mol) 2-methanesulfinyl-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine added and stirring was continued at 160° C. for 16 hours. Evaporation of the solvent and chromatography on silicagel with ethylacetate gave 0.2 g (83%) 2-phenethyloxy-7-pyridin-2-yl-[1,2,4]triazolo[1,5-a]pyridin-5-ylamine, MS m/e (%):332 (M+H+,100).

Provenance & Evidence