HCID 178418361, compound → HCID 178527242, compound

Participants

Reaction Steps

N-Azetidin-3-yl-N-(3,5-difluorophenyl)methylsulfonamide hydrochloride is obtained in the following manner: in a 500-cm3 hydrogenator, a solution of 1 g of N-(1-benzhydrylazetidin-3-yl)-N-(3,5-difluorophenyl)methylsulfonamide in a mixture of 2.5 cm3 of 1M hydrochloric acid and 0.41 cm3 of acetic acid is hydrogenated in the presence of 0.161 g of palladium hydroxide at a hydrogen pressure of 30 bar for 4 hours. The catalyst is removed by filtration on a celite bed and then the filtrate is concentrated to dryness at 40° C. under 2.7 kPa to give 630 mg of N-azetidin-3-yl-N-(3,5-difluorophenyl)methylsulfonamide, melting at 216° C.

Provenance & Evidence