Hydrogen Bromide → HCID 21896604, compound

Participants

Reaction Conditions

Reaction Steps

3-[Bromo(4-chlorophenyl)methyl]pyridine is obtained in the following manner: 3.5 cm3 of a 48% solution of hydrobromic acid in acetic acid and 1 cm3 of acetyl bromide are added to 1.5 g of (4-chlorophenyl)pyridin-3-ylmethanol. The amber-colored mixture thus obtained is heated under reflux for 4 hours and then cooled to 20° C., concentrated to dryness at 40° C. under 2.7 kPa, giving 1.53 g of 3-[bromo(4-chlorophenyl)methyl]pyridine (Rf=75/90, 254 nm, Silica Plates, reference 1.05719, Merck KGaA, 64271 Darmstatd, Germany).

Provenance & Evidence