Water → 2,5-Difluorophenol allyl ether

Participants

Reaction Conditions

Reaction Steps

10 g of 2,5-difluorophenol was dissolved in 120 ml dimethylformaldehyde, 21 g of potassium carbonate and 8.57 ml allyl bromide were added in this order thereto at room temperature and then the resulting mixture was stirred at 80° C. for 1 hour. After water was added to the reaction mixture, it was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and then evaporated. The resulting residue was subjected to silica gel chromatography (developing solvent: 5% ethyl acetate/n-hexane) to give 13 g of 2,5-difluorophenol allyl ether as a colorless oil.

Provenance & Evidence