Hydrochloric Acid → 2-Allyl-3,6-difluorophenol

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

13 g 2,5-difluorophenol allyl ether was dissolved in 90 ml N,N-dimethylaniline and stirred at 170° C. for 5 hours in a nitrogen stream. The reaction solution was poured into 10% aqueous hydrogen chloride solution and then extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and then evaporated The resulting residue was subjected to silica gel chromatography (developing solvent: 7% ethyl acetate/n-hexane) to give 7.8 g of 2-allyl-3,6-difluorophenol as a colorless oil.

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