Ethyl Acetate → HCID 22627651, compound

Participants

Reaction Steps

2-Acetoxymethyl-4,7-difluorobenzofuran (252 mg) was dissolved in 5 ml methanol, 455 mg potassium carbonate was added thereto at room temperature, and the mixture was stirred for 2 hours at the same temperature. Ethyl acetate was added to the reaction solution, and the organic layer was washed with brine. It was dried over anhydrous magnesium sulfate and then evaporated, and the resulting residue was subjected to silica gel chromatography (developing solvent: 5% ethyl acetate/n-hexane) to give 161 mg 4,7-difluoro-2-hydroxybenzofuran as a colorless oil.

Provenance & Evidence