反应详情

50 g of sodium carbonate was added at room temperature to a mixed solution of 400 ml water and 400 ml dioxane containing 10 g of the unpurified 3,4-dibromomethyl-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene, and the mixture was heated under reflux for 11 hours. The dioxane was removed, and then the residue was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and then evaporated. The resulting residue was subjected to silica gel column chromatography to give 1.6 g of the title compound as a yellow oil.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 11 hours
3. customThe dioxane was removed
4. extractionthe residue was extracted with ethyl acetate
5. washThe organic layer was washed with brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customevaporated