2,6-Difluoroaniline → [2-(2,6-Difluoroanilino)phenyl]acetic acid

HRID 277230Notes

Reaction equation

HRID 277230 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[F:12][C:13]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:14]=1[NH2:15]>>[F:12][C:13]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[C:14]=1[NH:15][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10]

Participants

3

Reactant 2

HCID 796472,6-DifluoroanilineHCID 877542-Bromophenylacetic acid

Product 1

HCID 13309832[2-(2,6-Difluoroanilino)phenyl]acetic acid

Procedure

In the manner described in example 3, 2-bromophenylacetic acid was condensed with 2,6-difluoroaniline to yield 2-[(2,6-difluorophenyl)amino]phenylacetic acid.

Sources & evidence

ORD record
ord-3406d85fdd7d478fb6e34d0ebecedd02
Source dataset
uspto-grants-2002_03
Patent number
US06355680B1

Reaction notes

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