反应详情

温度

50 °C

6-Chloro-7-cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazine (200 mg, 0.70 mmol) was suspended in methanol (8 ml). The mixture was saturated with ammonia and heated in a sealed tube at 50° C. overnight. The mixture was evaporated in vacuo, triturated (diethyl ether/hexane) and dried to give the title compound 1H NMR (360 MHz, d6-DMSO) δ 1.82-1.87 (1H, m), 1.99-2.35 (5H, m), 3.54-3.64 (1H, m), 7.34 (2H, vbs), 7.48-7.62 (3H, m), 8.08 (1H, s), 8.41 (2H, d, J=7.1 Hz); MS (ES+) m/e 266 [MH]+.

1. customThe mixture was evaporated in vacuo
2. customtriturated (diethyl ether/hexane)
3. customdried