N,N-Dimethylethylenediamine → HCID 18314529, compound

Participants

Reaction Steps

6-Chloro-7-cyclobutyl-3-phenyl-1,2,4-triazolo[4,3-b]pyridazine (100 mg, 0.35 mmol) and N,N-dimethylethylenediamine were heated together in a sealed tube at 60° C. for 24 h. The mixture was cooled and the white precipitate was collected by filtration and washed with diethyl ether, then dried to give the title compound. 1H NMR (250 MHz, CDCl3) δ 1.94 (1H, m), 2.12-2.24 (3H, m), 2.29 (6H, s), 2.41-2.50 (2H, m), 2.59-2.64 (2H, m), 3.38-3.49 (3H, m), 5.51 (1H, vbs), 7.41-7.52 (3H, m), 7.62 (1H, m), 8.54-8.62 (2H, m); MS (ES+) m/e 337 [MH]+.

Provenance & Evidence