HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Chloro-4-fluoro-5-nitrobenzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Chloro-4-fluoro-5-nitrobenzoic Acid | HCID 7210828 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2-Chloro-4-fluoro-5-nitrobenzoyl chloride | HCID 15124384 | — |
Reaction Steps
A mixture of 2-chloro-4-fluoro-5-nitrobenzoic acid (50.0 g, 0.228 mol) and N,N-dimethylformamide (5 drops) in 1,2-dichloroethane is treated dropwise with oxalyl chloride (30.8 mL, 0.353 mol), refluxed for 3 hours, cooled, and concentrated in vacuo to obtain the title product as an orange solid which is identified by NMR spectral analyses.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06355796B1 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-022def1681e94c3f87923f294e8f357d |
| Source note | uspto-grants-2002_03 |