Nitric Acid → HCID 57032799, compound

HRID 277417Notes

Reaction equation

HRID 277417 reaction equation
[Cl:1][C:2]1[C:7]([NH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][C:5]([N:14]2[C:19](=[O:20])[CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[NH:16][C:15]2=[O:25])=[C:4]([F:26])[CH:3]=1.S(=O)(=O)(O)O.[N+:32]([O-])([OH:34])=[O:33]>>[Cl:1][C:2]1[CH:3]=[C:4]([F:26])[C:5]([N:14]2[C:19](=[O:20])[CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[NH:16][C:15]2=[O:25])=[C:6]([N+:32]([O-:34])=[O:33])[C:7]=1[NH:8][C:9]([O:11][CH2:12][CH3:13])=[O:10]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric Acid2×HCID 57090489HCID 57090489, compound

Product 1

HCID 57032799HCID 57032799, compound

Procedure

3-(4Chloro-5-ethoxycarbonylamino-2-fluorophenyl)-6-trifluoromethyl-2,4(1H, 3H)-pyrimidinedione (XLVII) (1.0 g) was stirred with sulfuric acid (2 ml) at 0° C., then a mixture of nitric acid (1 ml) and sulfuric acid (1 ml) was dropwise added. After stirring at room temperature for 3 hr, it was poured into ice water (50 ml) and yellow crystals formed immediately which was filtered, washed with water and dried in fume hood overnight (0.5 g).

Workup

  1. additionwas dropwise added
  2. customformed immediately which
  3. filtrationwas filtered
  4. washwashed with water
  5. customdried in fume hood overnight (0.5 g)

Sources & evidence

ORD record
ord-7850481a5cd84e0a9ed9330a8fabd701
Source dataset
uspto-grants-2002_03
Patent number
US06355799B1

Reaction notes

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