HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 2,3-dihydro-2,5-dimethyl-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | 2,3-dihydro-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile | HCID 12570234 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2,3-dihydro-2,5-dimethyl-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile | HCID 23342012 | — |
Reaction Steps
A mixture of 10 parts of 2,3-dihydro-3oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile, 45 parts of iodomethane, and 95 parts of N,N-dimethylformamide is heated at 100° for 2 hours, then diluted with 100 parts of water. The precipitate which forms is filtered out, dried in vacuo, and recrystallized from ethanol to give 2,3-dihydro-2,5-dimethyl-3-oxo-5H-pyrido[3,4-b][1,4]benzothiazine-4-carbonitrile melting at approximately 236°-237°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04223136 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-af2db1a877d349b0b30c7325e13f017e |
| Source note | uspto-grants-1980_09 |