Sodium Hydroxide → HCID 22596780, compound

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Methyl 2-ethoxy-1-[[2′-(methoxycarbonyl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate	HCID 15654679	—
Solvent	Methanol	HCID 887	—
Product	HCID 22596780	HCID 22596780	83%

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a solution of methyl 2-ethoxy-1-[(2′-methoxycarbonylbiphenyl-4-yl)methyl]benzimidazole-7-carboxylate (0.7 g) in methanol (10 ml) was added 1N NaOH (5 ml) and the mixture was stirred at 80° C. for 3 hours. After evaporation of the methanol, the aqueous residue was neutralized with 1N hydrochloric acid to give crystals. The crystals were recrystallized from methanol-chloroform to afford colorless crystals (0.54 g, 83%), m.p. 213-215° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06355808B2
Source dataset	uspto-grants-2002_03
ORD ID	ord-9775ca1e3b3848d89db1e0440f02d640
Source note	uspto-grants-2002_03