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Phosphorus oxychloride → Ethyl 2-chloro-5-cyano-6-methylnicotinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | HCID 178469023 | HCID 178469023 | — |
| 生成物 | Ethyl 2-chloro-5-cyano-6-methylnicotinate | HCID 2758816 | — |
反応手順
200 g of 5-cyano-2-hydroxy-6-methyl-3-pyridine-carboxylic acid, ethyl ester (1 mol) are refluxed with stirring in 750 ml of phosphorous oxychloride for 5 hours. The excess of phosphorous oxychloride is removed in vacuo and the residue poured in 1 kg of ice. 2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester crystallizes and is filtered off. Yield 170 g (76%); m.p. 43°-45° C. (petrol ether).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04223142 |
| 出典データセット | uspto-grants-1980_09 |
| ORD ID | ord-7bb211f2fe674db5b482addbf408b649 |
| 出典メモ | uspto-grants-1980_09 |