反应详情

112 g of 2-chloro-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester (0.5 mol) are dissolved in 300 ml of alcohol and 73 g of n-butylamine are dropped in at reflux temperature with stirring. After the addition is completed, the mixture is refluxed for an additional hour and then poured onto ice. 2-butylamino-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester precipitates. Yield 116 g (89%); m.p. 61°-63° C. (petrol ether).

1. temperatureat reflux temperature
2. additionAfter the addition
3. temperaturethe mixture is refluxed for an additional hour
4. additionpoured onto ice
5. custom2-butylamino-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester precipitates