Selenium Dioxide → 2-Butylamino-5-cyano-6-formyl-3-pyridine-carboxylic acid, ethyl ester

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Reaction Steps

130.5 g of 2-butylamino-5-cyano-6-methyl-3-pyridine-carboxylic acid, ethyl ester (0.5 mol) are dissolved in 400 ml of diethyleneglycoldimethyl ether. 61.1 g of selenium dioxide are added and the mistrue is heated at reflux temperature for 1 hour. The mixture is filtered hot and evaporated to dryness. The resulting yellow oil of 2-butylamino-5-cyano-6-formyl-3-pyridine-carboxylic acid, ethyl ester is crystallized with diethyl ether. Yield 95 g (69%); m.p. 81°-83° C. (methanol).

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