4-Methoxy-3-(morpholine-4-sulfonyl)benzoic acid → 2-[(E)-2-[2-(Isopropoxysulfonyl)-4-[[4-(methylsulfonyl)benzoyl]amino]phenyl]ethenyl]-5-[[4-methoxy-3-(4-morpholinylsulfonyl)benzoyl]amino]benzenesulfonic acid, (1-Methylethyl) Ester
Reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][C:4]=1[S:12]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)(=[O:14])=[O:13].[CH3:21][S:22]([C:25]1[CH:56]=[CH:55][C:28]([C:29]([NH:31][C:32]2[CH:33]=[CH:34][C:35](/[CH:42]=[CH:43]/[C:44]3[CH:49]=[CH:48][C:47]([NH2:50])=[CH:46][C:45]=3[S:51]([OH:54])(=[O:53])=[O:52])=[C:36]([S:38]([O-:41])(=[O:40])=[O:39])[CH:37]=2)=[O:30])=[CH:27][CH:26]=1)(=[O:24])=[O:23]>>[CH:3]([O:39][S:38]([C:36]1[CH:37]=[C:32]([NH:31][C:29](=[O:30])[C:28]2[CH:27]=[CH:26][C:25]([S:22]([CH3:21])(=[O:23])=[O:24])=[CH:56][CH:55]=2)[CH:33]=[CH:34][C:35]=1/[CH:42]=[CH:43]/[C:44]1[CH:49]=[CH:48][C:47]([NH:50][C:7](=[O:9])[C:6]2[CH:10]=[CH:11][C:3]([O:2][CH3:1])=[C:4]([S:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)(=[O:14])=[O:13])[CH:5]=2)=[CH:46][C:45]=1[S:51]([O:54][CH:6]([CH3:7])[CH3:5])(=[O:52])=[O:53])(=[O:41])=[O:40])([CH3:11])[CH3:4]Participants
3
Reactant 2
Product 1
Procedure
From 4-methoxy-3-(morpholine-4-sulfonyl)-benzoic acid, Example 1a and 5-[[4-(methylsulfonyl)benzoyl]amino]-2-[(E)-2-[4-amino-2-sulfophenyl]ethenyl]benzenesulfonate, bis(1-methylethyl) ester, Example 28b (52%): MS (−ESI): [M−H]− 918.
Sources & evidence
- ORD record
- ord-b7837201ddaa491f9bfe6600039d989c
- Source dataset
- uspto-grants-2002_03
- Patent number
- US06355633B1
Reaction notes
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