HuagongsheHuagongshe Chemistry Print Report · For research reference only
Selenium Dioxide → 5-Cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Selenium Dioxide | HCID 24007 | — |
| Reactant | 5-Cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester | HCID 86737217 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 5-Cyano-6-formyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester | HCID 86737216 | — |
Reaction Steps
27 g of 5-cyano-6-methyl-2-piperidinyl-3-pyridine-carboxylic acid, ethyl ester (0.1 mol) and 12.2 g selenium dioxide (0.11 mol) are refluxed together in diethyleneglycoldimethyl ether with stirring for 1.5 hours. The solvent is distilled off in vacuo and the oily residue crystallized with diethyl ether. Yield 19 g (66%); m.p. 62°-64° C. (ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04223142 |
| Source dataset | uspto-grants-1980_09 |
| ORD ID | ord-08848c8983c8401ca0f082b68172436a |
| Source note | uspto-grants-1980_09 |