Acetone → HCID 86583597, compound

Participants

Reaction Steps

Then, this is reacted with chloromethyloxirane in the presence of a deacidification agent, e.g. potassium carbonate, in acetone, methyl ethyl ketone or acetonitrile to form (2,3-epoxy)glycidylhydroquinone derivative (VIII). 1-(2,3,5-trimethyl-4-acetoxyphenoxy)-2,3-epoxypropane, in particular, can be synthesized by a method described in Czechoslovak Patent No.7704666. Then this is subjected to addition reaction with a phenylpiperazine derivative in heated alcohol or dioxane to form compound (XI), the protecting acyl or benzyl group of which then is cleaved with a base or by catalytic reduction to give the present compound, a hydroquinone derivative (II).

Provenance & Evidence