HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 1-(2-Methyl-4-hydroxynaphthoxy)-3-[4-(2-methylphenyl)-1-piperazinyl] propan-2-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Benzyloxy-2-methylnaphthol | HCID 12051654 | — |
| Reactant | 1-(o-Tolyl)piperazine Hydrochloride | HCID 12227895 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(2-Methyl-4-hydroxynaphthoxy)-3-[4-(2-methylphenyl)-1-piperazinyl] propan-2-ol hydrochloride | HCID 22625423 | — |
Reaction Steps
Using 3.7 g of 4-benzyloxy-2-methylnaphthol, 1.4 g of anhydrous potassium carbonate, 5.0 g of chloromethyloxirane, 2.2 g of 1-(2-tolyl)piperazine hydrochloride and 1.2 g of triethylamine, reaction was carried out as in Examples 1-A and 2. The thus obtained crystals were recrystallized from ethanol-isopropyl ether to give 2.3 g, m.p. 261-263° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358515B2 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-e6b61e3e6c244d708c33ce13a71fe969 |
| Source note | uspto-grants-2002_03 |