HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 1-(3-Methyl-4-benzyloxynaphthoxy)-3-[4-(2-fluorophenyl)-1-piperazinyl] propan-2-ol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-(2-Fluorophenyl)piperazine Hydrochloride | HCID 2734698 | — |
| Reactant | 4-Benzyloxy-3-methylnaphthol | HCID 12051652 | — |
| Product | 1-(3-Methyl-4-benzyloxynaphthoxy)-3-[4-(2-fluorophenyl)-1-piperazinyl] propan-2-ol hydrochloride | HCID 22625413 | 57.7% |
Reaction Steps
Using 5.3 g (0.02 mol) of 4-benzyloxy-3-methylnaphthol, 2.8 g (0.02 mol) of anhydrous potassium carbonate, 9.3 g (0.10 mol) of chloromethyloxirane, 4.3 g (0.02 mol) of 1-(2-fluorophenyl)piperazine hydrochloride and 2.0 g (0.02 mol) of triethylamine, reaction was carried out as in Example 1-A to give 6.2 g of white crystals, m.p. 218-220° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358515B2 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-8eb5b2a72c584945bc786e773d3e341d |
| Source note | uspto-grants-2002_03 |