HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 1-(2-Methyl-4-hydroxynaphthoxy)-3-[4-(2,4-dimethoxyphenyl)-1-piperazinyl] propan-2-ol dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 22625378 | HCID 22625378 | — |
| Reactant | 4-Benzoyloxy-2-methylnaphthol | HCID 22625409 | — |
| Product | 1-(2-Methyl-4-hydroxynaphthoxy)-3-[4-(2,4-dimethoxyphenyl)-1-piperazinyl] propan-2-ol dihydrochloride | HCID 22625392 | 13.3% |
Reaction Steps
Using 2.8 g (0.01 mol) of 4-benzoyloxy-2-methylnaphthol, 1.4 g (0.01 mol) of anhydrous potassium carbonate, 4.6 g (0.05 mol) of chloromethyloxirane, 2.9 g (0.01 mol) of 1-(2,4-dimethoxyphenyl)piperazine dihydrochloride and 2.0 g (0.02 mol) of triethylamine, reaction was carried out as in Examples 2 and 4 to give 0.7 g of crystals, m.p. 175-177° C. (decomp.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358515B2 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-3d0e2e1168804c138e4e559302229c25 |
| Source note | uspto-grants-2002_03 |