Epichlorohydrin → HCID 22625394, compound

Participants

Reaction Steps

Then, using 6.07 g of the compound of Example 18 above, 4.0 ml of chloromethyloxirane, 3.26 g of anhydrous potassium carbonate and 100 ml of methyl methyl ketone, reaction and workup carried out as in 1-A gave about 8.00 g of 1-(4-benzyloxy-3-tert-butylphenoxy)-2,3-epoxypropane as brown oil. Using the epoxy compound thus obtained, 4.82 g of 1-(2-methoxyphenyl)piperazine and 100 ml of dioxane, reaction and workup carried out as in Example 1-A followed by recrystallization from isopropyl ether gave 6.48 g of white crystals, m.p. 133-134° C.

Provenance & Evidence