HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → 1-(4-Benzyloxyphenoxy)-3-[4-(2-methoxy-5-methylphenyl)-1-piperazinyl]propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | ((p-(Benzyloxy)phenoxy)methyl)oxirane | HCID 119882 | — |
| Reactant | HCID 22625397 | HCID 22625397 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(4-Benzyloxyphenoxy)-3-[4-(2-methoxy-5-methylphenyl)-1-piperazinyl]propan-2-ol | HCID 22625405 | 89.5% |
Reaction Steps
Using 1.37 g of 1-(4-benzyloxyphenoxy)-2,3-epoxypropane, 50 ml of dioxane, 1.49 g of 1-(2-methoxy-5-methylphenyl)piperazine dihydrochloride and 1.6 ml of triethylamine, reaction and workup were carried out as in Example 1-A. Purification by column chromatography (silica gel, elution with ethyl acetate:hexane=1:1) gave 2.21 g of pale yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06358515B2 |
| Source dataset | uspto-grants-2002_03 |
| ORD ID | ord-69d41a5bc4b94670b9a110e6d04c642f |
| Source note | uspto-grants-2002_03 |