Tetrahydrofuran → HCID 15508715, compound

Participants

Reaction Conditions

Reaction Steps

A couple of Zn—Cu (50 g) and tetrahydrofuran (90 ml) were placed in a four-necked round flask equipped with a stirrer and reflux condenser and then, a mixing solution of t-butylbromoacetate (53 ml) and 5-norbornene-2-carboxaadehyde (36 ml) dissolved in tetrahydrofuran 180 ml was slowly added to the flask. The resulting solution was refluxed at 70° C. for 2 hours and cooled into room temperature. After separating a couple of Zn—Cu from the solution, the remaining solution was extracted, washed with a solvent and distilled under reduced pressure to obtain 3-bicyclo[2,2,1]hept-5-ene-2-yl-3-hydroxyl-propionic acid t-butyl ester (hereinafter referred to as “BHP”, M-I) as a monomer (39 g).

Provenance & Evidence