6-Chlorobenzo[b]thiophene-2-sulfonyl chloride → 6-Chlorobenzo[b]thiophene-2-sulfonic acid [1-(5-cyano-2-hydroxy-benzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

Participants

Reaction Steps

The title compound is prepared from 3-[(3-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-hydroxy-benzonitrile hydrochloride as described in EXAMPLE 17, Part G substituting 6-chlorobenzo[b]thiophene-2-sulfonyl chloride in place of 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The crude product is triturated with Et2O to give the title compound as a white solid.

Provenance & Evidence