Sodium borohydride → HCID 22625979, compound

Participants

Reaction Steps

To a 0° C. solution of 9 (9.33 g, 24.6 mmol) in dioxane (250 mL) was added NaBH4 (1.02 g, 27.1 mmol) in one portion. The solution stirred for two hours at room temperature. The solvent was removed in vacuo, and the residue was partitioned between CHCl3 and 1 N HCl. The aqueous layer was extracted with CHCl3, and the combined organic extracts were dried, concentrated, and purified by PCTLC (1:1 EtOAc:Hex). A white solid was obtained. 1H NMR (CDCl3, 400 MHz) 7.30-7.04 (m, 6H), 6.93-6.83 (m, 6H), 5.58 (s, 1H), 5.18-5.04 (q, 2H), 3.77 (s, 3H).

Provenance & Evidence