Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzyl piperazine-1-carboxylate | HCID 643495 | — |
| Reactant | 1-(4-Cyanobenzyl)-5-(chloromethyl)imidazole | HCID 9795358 | — |
| Product | HCID 86585292 | HCID 86585292 | — |
Reaction Steps
To an acetonitrile solution of 1-(4′-cyanobenzyl)-5-chloromethylimidazole (7.45 mmol), prepared as described in Example 1, Step 4, and diisopropylethyl amine (22.4 mmol) was added 1-benzyl 1-piperazine carboxylate (10.4 mmol). This solution was stirred for 4.0 hours at 80° C. The product was isolated after silica column purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06358956B1 |
|---|
| Source dataset | uspto-grants-2002_03 |
|---|
| ORD ID | ord-14e3240f81134453bac847871c84090e |
|---|
| Source note | uspto-grants-2002_03 |
|---|
