反应详情

温度

10 °C

3.28 g of 5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxy-3,4-dihydrocarbostyril hydrochloride was dissolved in 50 ml of methanol, and a 10% methanolic solution of sodium methylate was added to the solution in an amount of 2 moles per mole of the starting carbostyril compound. The resulting mixture was concentrated to dryness, and the residue was dissolved in dimethylformamide. 1.6 g of cyclohexanecarboxylic acid chloride was added to the solution and the mixture was stirred for 2 hours at a temperature of 10° C. The reaction mixture was poured into ice-water and the mixture was extracted with chloroform. A mixture of diethyl ether and petroleum benzene was added to the extract to obtain 1.2 g of crystalline 8-cyclohexylcarbonyloxy-5-(1-hydroxy-2-isopropylaminobutyl)-3,4-dihydrocarbostyril having a melting point of 148°-149° C. (after recrystallization from chloroform-n-hexane).

1. concentrationThe resulting mixture was concentrated to dryness
2. dissolutionthe residue was dissolved in dimethylformamide
3. addition1.6 g of cyclohexanecarboxylic acid chloride was added to the solution
4. additionThe reaction mixture was poured into ice-water
5. extractionthe mixture was extracted with chloroform
6. additionA mixture of diethyl ether and petroleum benzene
7. additionwas added to the
8. extractionextract